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Keratin 17 regulates nuclear morphology and chromatin organization

Keratin 17 (KRT17; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei re...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Jacob, Justin T., Nair, Raji R., Poll, Brian G., Pineda, Christopher M., Hobbs, Ryan P., Matunis, Michael J., Coulombe, Pierre A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648610/
https://ncbi.nlm.nih.gov/pubmed/33008845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.254094
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