Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus

Antibodies to double-stranded DNA (dsDNA) are prevalent in systemic lupus erythematosus (SLE), particularly in patients with lupus nephritis, yet the nature and regulation of antigenic cell-free DNA (cfDNA) are poorly understood. Null mutations in the secreted DNase DNASE1L3 cause human monogenic SL...

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Udgivet i:J Exp Med
Main Authors: Hartl, Johannes, Serpas, Lee, Wang, Yueyang, Rashidfarrokhi, Ali, Perez, Oriana A., Sally, Benjamin, Sisirak, Vanja, Soni, Chetna, Khodadadi-Jamayran, Alireza, Tsirigos, Aristotelis, Caiello, Ivan, Bracaglia, Claudia, Volpi, Stefano, Ghiggeri, Gian Marco, Chida, Asiya Seema, Sanz, Ignacio, Kim, Mimi Y., Belmont, H. Michael, Silverman, Gregg J., Clancy, Robert M., Izmirly, Peter M., Buyon, Jill P., Reizis, Boris
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020718/
https://ncbi.nlm.nih.gov/pubmed/33783474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201138
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