Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain

INTRODUCTION: New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful stimuli by neuron hyperpolarization via nitric oxide (NO)/cyclic 3ʹ,5ʹ-guanosine monophosphate (cGMP) pathway. The present work investi...

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Udgivet i:J Pain Res
Main Authors: Vieira, Marcio Carneiro, Monte, Fernanda Bezerra de Mello, Eduardo Dematte, Bruno, Montagnoli, Tadeu Lima, Montes, Guilherme Carneiro, da Silva, Jaqueline Soares, Mendez-Otero, Rosalia, Trachez, Margarete Manhães, Sudo, Roberto Takashi, Zapata-Sudo, Gisele
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020462/
https://ncbi.nlm.nih.gov/pubmed/33833563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S295265
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