Novel agonist of α(4)β(2)* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain

OBJECTIVE: To demonstrate the antinociceptive and antihypersensitivity mechanisms of Cris-104 (1-{2-[5-(4-fluorophenyl)–1H-pyrazol-4-yl]ethyl}piperidine), a novel selective α(4)β(2)* nicotinic acetylcholine receptor (nAChR) agonist, in rodent acute/inflammatory and chronic pain models. MATERIALS AND...

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Vydáno v:J Pain Res
Hlavní autoři: Sudo, Roberto T, Hayashida, Kenichiro, Santos, Aluizio N, Kawatani, Masahito, Monteiro, Carlos ES, Moreira, Roberto D, Trachez, Margarete M, Montes, Guilherme C, Zapata-Sudo, Gisele
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2018
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214310/
https://ncbi.nlm.nih.gov/pubmed/30464575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S169637
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