Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) arises in a cirrhotic, pro-angiogenic microenvironment. Inhibiting angiogenesis is a key mode of action of multikinase inhibitors and current non-cirrhotic models are unable to predict treatment response. We present a novel mouse cirrhotic model...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Huang, Daniel Q., Muthiah, Mark D., Zhou, Lei, Jumat, Halisah, Tan, Wan Xin, Lee, Guan Huei, Lim, Seng Gee, Kow, Alfred, Bonney, Glenn, Shridhar, Iyer, Lim, Yi Ting, Wee, Aileen, Pang, Yin Huei, Soon, Gwyneth, Chow, Pierce, Dan, Yock Young
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020437/
https://ncbi.nlm.nih.gov/pubmed/33340714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.12.009
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