Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) arises in a cirrhotic, pro-angiogenic microenvironment. Inhibiting angiogenesis is a key mode of action of multikinase inhibitors and current non-cirrhotic models are unable to predict treatment response. We present a novel mouse cirrhotic model...

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Vydáno v:Cell Mol Gastroenterol Hepatol
Hlavní autoři: Huang, Daniel Q., Muthiah, Mark D., Zhou, Lei, Jumat, Halisah, Tan, Wan Xin, Lee, Guan Huei, Lim, Seng Gee, Kow, Alfred, Bonney, Glenn, Shridhar, Iyer, Lim, Yi Ting, Wee, Aileen, Pang, Yin Huei, Soon, Gwyneth, Chow, Pierce, Dan, Yock Young
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020437/
https://ncbi.nlm.nih.gov/pubmed/33340714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.12.009
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