A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

Na(v)1.5, encoded by the gene SCN5A, is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function. Dysfunctions in Na(v)1.5 have been involved in multiple congenital or acquired cardiac path...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Zheng, Yang, Wan, Xiaoping, Yang, Dandan, Ramirez-Navarro, Angelina, Liu, Haiyan, Fu, Ji-Dong, Deschênes, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8019726/
https://ncbi.nlm.nih.gov/pubmed/33828490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.661429
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