Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Chronic kidney disease (CKD) worsens ischemic stroke severity in both patients and animals. In mice, these poorer functional outcomes are associated with decreased brain activity of AMP-activated protein kinase (AMPK), a molecule that recently emerged as a potential therapeutic target for ischemic s...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Grissi, Maria, Boudot, Cédric, Assem, Maryam, Candellier, Alexandre, Lando, Mathilde, Poirot-Leclercq, Sabrina, Boullier, Agnès, Bennis, Youssef, Lenglet, Gaëlle, Avondo, Carine, Lalau, Jean-Daniel, Choukroun, Gabriel, Massy, Ziad A., Kamel, Saïd, Chillon, Jean-Marc, Hénaut, Lucie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018962/
https://ncbi.nlm.nih.gov/pubmed/33811249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86905-9
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