Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Chronic kidney disease (CKD) worsens ischemic stroke severity in both patients and animals. In mice, these poorer functional outcomes are associated with decreased brain activity of AMP-activated protein kinase (AMPK), a molecule that recently emerged as a potential therapeutic target for ischemic s...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Grissi, Maria, Boudot, Cédric, Assem, Maryam, Candellier, Alexandre, Lando, Mathilde, Poirot-Leclercq, Sabrina, Boullier, Agnès, Bennis, Youssef, Lenglet, Gaëlle, Avondo, Carine, Lalau, Jean-Daniel, Choukroun, Gabriel, Massy, Ziad A., Kamel, Saïd, Chillon, Jean-Marc, Hénaut, Lucie
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018962/
https://ncbi.nlm.nih.gov/pubmed/33811249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86905-9
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