Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer’s Disease Mice

Alzheimer’s disease (AD) is the most common cause of senile dementia and one of the greatest medical, social, and economic challenges. According to a dominant theory, amyloid-β (Aβ) peptide is a key AD pathogenic factor. Aβ-soluble species interfere with synaptic functions, aggregate gradually, form...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Neurobiol
Egile Nagusiak: Fonar, Gennadiy, Polis, Baruh, Sams, Dev Sharan, Levi, Almog, Malka, Assaf, Bal, Natalia, Maltsev, Alexander, Elliott, Evan, Samson, Abraham O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer US 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018932/
https://ncbi.nlm.nih.gov/pubmed/33417228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-020-02270-0
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