Construction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancer

Chimeric antigen receptor (CAR) T cell is a promising method in cancer immunotherapy but faces many challenges in solid tumors. One of the major problems was immunosuppression caused by PD-1. In our study, the expression of c-Met in GC was analyzed from TCGA datasets, GC tissues, and cell lines. The...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Chen, Cong, Gu, Yan-Mei, Zhang, Fan, Zhang, Zheng-Chao, Zhang, Ya-Ting, He, Yi-Di, Wang, Ling, Zhou, Ning, Tang, Fu-Tian, Liu, Hong-Jian, Li, Yu-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018404/
https://ncbi.nlm.nih.gov/pubmed/33854821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1901434
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