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Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of he...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Iwahashi, Naoyuki, Ikezaki, Midori, Saito, Hiroyuki, Uchimura, Kenji, Nishitsuji, Kazuchika
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018399/
https://ncbi.nlm.nih.gov/pubmed/33860088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2021.1892444
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