Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates

Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) are heteropolysaccharides implicated in the pathology of protein aggregation diseases including localized and systemic forms of amyloidosis. Among subdomains of sulfated GAGs, highly sulfated domains of HS, called HS S-domains, have bee...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Iwahashi, Naoyuki, Ikezaki, Midori, Nishikawa, Taro, Namba, Norihiro, Ohgita, Takashi, Saito, Hiroyuki, Ihara, Yoshito, Shimanouchi, Toshinori, Ino, Kazuhiko, Uchimura, Kenji, Nishitsuji, Kazuchika
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776818/
https://ncbi.nlm.nih.gov/pubmed/33318190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009931117
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