High‐dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy

Biotin is an essential cofactor for carboxylases that regulates the energy metabolism. Recently, high‐dose pharmaceutical‐grade biotin (MD1003) was shown to improve clinical parameters in a subset of patients with chronic progressive multiple sclerosis. To gain insight into the mechanisms of action,...

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Bibliographic Details
Published in:Brain Pathol
Main Authors: Fourcade, Stéphane, Goicoechea, Leire, Parameswaran, Janani, Schlüter, Agatha, Launay, Nathalie, Ruiz, Montserrat, Seyer, Alexandre, Colsch, Benoit, Calingasan, Noel Ylagan, Ferrer, Isidre, Beal, M. Flint, Sedel, Frédéric, Pujol, Aurora
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018149/
https://ncbi.nlm.nih.gov/pubmed/32511826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12869
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