IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions

A hallmark of cancer, including pancreatic ductal adenocarcinoma (PDA), is a massive stromal and inflammatory reaction. Many efforts have been made to identify the anti- or protumoral role of cytokines and immune subpopulations within the stroma. Here, we investigated the role of interleukin-17A (IL...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Mucciolo, Gianluca, Curcio, Claudia, Roux, Cecilia, Li, Wanda Y., Capello, Michela, Curto, Roberta, Chiarle, Roberto, Giordano, Daniele, Satolli, Maria Antonietta, Lawlor, Rita, Scarpa, Aldo, Lukac, Pavol, Stakheev, Dmitry, Provero, Paolo, Vannucci, Luca, Mak, Tak W., Novelli, Francesco, Cappello, Paola
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2021
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017922/
https://ncbi.nlm.nih.gov/pubmed/33526692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020395118
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