IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions

A hallmark of cancer, including pancreatic ductal adenocarcinoma (PDA), is a massive stromal and inflammatory reaction. Many efforts have been made to identify the anti- or protumoral role of cytokines and immune subpopulations within the stroma. Here, we investigated the role of interleukin-17A (IL...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mucciolo, Gianluca, Curcio, Claudia, Roux, Cecilia, Li, Wanda Y., Capello, Michela, Curto, Roberta, Chiarle, Roberto, Giordano, Daniele, Satolli, Maria Antonietta, Lawlor, Rita, Scarpa, Aldo, Lukac, Pavol, Stakheev, Dmitry, Provero, Paolo, Vannucci, Luca, Mak, Tak W., Novelli, Francesco, Cappello, Paola
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017922/
https://ncbi.nlm.nih.gov/pubmed/33526692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020395118
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