A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids

BACKGROUND: There is an urgent need for approaches to prevent and treat SARS-CoV-2 infection. Administration of soluble ACE2 protein acting as a decoy to bind to SARS-CoV-2 should limit viral uptake mediated by binding to membrane-bound full-length ACE2, and further therapeutic benefit should result...

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Publicat a:J Am Soc Nephrol
Autors principals: Wysocki, Jan, Ye, Minghao, Hassler, Luise, Gupta, Ashwani Kumar, Wang, Yuguo, Nicoleascu, Vlad, Randall, Glenn, Wertheim, Jason A., Batlle, Daniel
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2021
Matèries:
Rapid Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017551/
https://ncbi.nlm.nih.gov/pubmed/33526471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020101537
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