A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2), which is membrane bound, as its initial cell contact receptor preceding viral entry. Here we report a human soluble ACE2 variant fused with a 5kD albumin binding domain (ABD) an...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Hassler, Luise, Wysocki, Jan, Gelarden, Ian, Tomatsidou, Anastasia, Gula, Haley, Nicoleascu, Vlad, Randall, Glenn, Henkin, Jack, Yeldandi, Anjana, Batlle, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987000/
https://ncbi.nlm.nih.gov/pubmed/33758841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.12.435191
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