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In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST(4) Receptor Agonists
Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST(4)) without influencing endocrine functions. Therefore, SST(4) is considered to be a novel target for drug development in pain, especially ch...
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| Publicado no: | Front Pharmacol |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8015869/ https://ncbi.nlm.nih.gov/pubmed/33815096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.601887 |
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