WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis

Epithelioid hemangioendothelioma (EHE) is a genetically homogenous vascular sarcoma that is a paradigm for TAZ dysregulation in cancer. EHE harbors a WWTR1(TAZ)-CAMTA1 gene fusion in >90% of cases, 45% of which have no other genetic alterations. In this study, we used a first of its kind approach...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Seavey, Caleb N., Pobbati, Ajaybabu V., Hallett, Andrea, Ma, Shuang, Reynolds, Jordan P., Kanai, Ryan, Lamar, John M., Rubin, Brian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2021
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015722/
https://ncbi.nlm.nih.gov/pubmed/33766982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.348220.120
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