Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38

p53 is critical for tumor suppression but also elicits detrimental effects when aberrantly overexpressed. Thus, multiple regulators, including RNA-binding protein RBM38, are found to tightly control p53 expression. Interestingly, RBM38 is unique in that it can either suppress or enhance p53 mRNA tra...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Sun, Wenqiang, Laubach, Kyra, Lucchessi, Christopher, Zhang, Yanhong, Chen, Mingyi, Zhang, Jin, Chen, Xinbin
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015715/
https://ncbi.nlm.nih.gov/pubmed/33664057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.346148.120
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