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Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression
Rbm38 is a p53 target and a RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to p53 mRNA. In this study, we show that synthetic peptides corresponding to the binding interface between Rbm38 and eIF4E, including an 8...
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| Publié dans: | Cancer Res |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377842/ https://ncbi.nlm.nih.gov/pubmed/30591552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2209 |
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