Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes

Maximizing the probability of antigen presentation to T cells through diversity in HLAs can enhance immune responsiveness and translate into improved clinical outcomes, as evidenced by the association of heterozygosity and supertypes at HLA class I loci with improved survival in patients with advanc...

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Publicat a:Transplant Cell Ther
Autors principals: Camacho-Bydume, Christine, Wang, Tao, Sees, Jennifer A., Fernandez-Viña, Marcelo, Abid, Muhammad Bilal, Askar, Medhat, Beitinjaneh, Amer, Brown, Valerie, Castillo, Paul, Chhabra, Saurabh, Gadalla, Shahinaz M., Hsu, Jing-Mei, Kamoun, Malek, Lazaryan, Aleksandr, Nishihori, Taiga, Page, Kristin, Schetelig, Johannes, Fleischhauer, Katharina, Marsh, Steven G.E., Paczesny, Sophie, Spellman, Stephen R., Lee, Stephanie J., Hsu, Katharine C.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015676/
https://ncbi.nlm.nih.gov/pubmed/33053450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2020.10.010
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