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Intra-lacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects Without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren’s Syndrome
Sjögren’s syndrome (SS) is an autoimmune disease associated with severe exocrinopathy, which is characterized by profound lymphocytic infiltration (dacryoadenitis) and loss of function of the tear-producing lacrimal glands (LG). Systemic administration of Rapamycin (Rapa) significantly reduces LG in...
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| Опубликовано в: : | Biomacromolecules |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8015671/ https://ncbi.nlm.nih.gov/pubmed/33356170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.0c01468 |
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