Innovative therapeutic strategy using prostaglandin I(2) agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension

Clinical outcomes of pulmonary arterial hypertension (PAH) may be improved using targeted delivery system. We investigated the efficacy of ONO1301 (prostacyclin agonist) nanospheres (ONONS) in Sugen5416/hypoxia rat models of PAH. The rats were injected with saline (control) or ONONS (n = 10, each) o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kanaya, Tomomitsu, Miyagawa, Shigeru, Kawamura, Takuji, Sakai, Yoshiki, Masada, Kenta, Nawa, Nobutoshi, Ishida, Hidekazu, Narita, Jun, Toda, Koichi, Kuratani, Toru, Sawa, Yoshiki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012709/
https://ncbi.nlm.nih.gov/pubmed/33790393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86781-3
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