Innovative therapeutic strategy using prostaglandin I(2) agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension

Clinical outcomes of pulmonary arterial hypertension (PAH) may be improved using targeted delivery system. We investigated the efficacy of ONO1301 (prostacyclin agonist) nanospheres (ONONS) in Sugen5416/hypoxia rat models of PAH. The rats were injected with saline (control) or ONONS (n = 10, each) o...

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Publicado en:Sci Rep
Autores principales: Kanaya, Tomomitsu, Miyagawa, Shigeru, Kawamura, Takuji, Sakai, Yoshiki, Masada, Kenta, Nawa, Nobutoshi, Ishida, Hidekazu, Narita, Jun, Toda, Koichi, Kuratani, Toru, Sawa, Yoshiki
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012709/
https://ncbi.nlm.nih.gov/pubmed/33790393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86781-3
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