Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by several pathologies including oxidative stress, apoptosis, neuroinflammation, and glutamate toxicity. Although multiple reports suggest that ischemia and hypoxia in the spinal cord plays a pivotal role in...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Tada, Satoru, Okuno, Tatsusada, Shimizu, Mikito, Sakai, Yoshiki, Sumi-Akamaru, Hisae, Kinoshita, Makoto, Yamashita, Kazuya, Sanda, Eri, Choong, Chi-Jing, Namba, Akiko, Sasaki, Tsutomu, Koda, Toru, Takata, Kazushiro, Miyagawa, Shigeru, Sawa, Yoshiki, Nakatsuji, Yuji, Mochizuki, Hideki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437213/
https://ncbi.nlm.nih.gov/pubmed/30918303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41771-4
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