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Low Diversity of Human Variation Despite Mostly Mild Functional Impact of De Novo Variants

Non-synonymous Single Nucleotide Variants (nsSNVs), resulting in single amino acid variants (SAVs), are important drivers of evolutionary adaptation across the tree of life. Humans carry on average over 10,000 SAVs per individual genome, many of which likely have little to no impact on the function...

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Bibliografische gegevens
Gepubliceerd in:Front Mol Biosci
Hoofdauteurs: Mahlich, Yannick, Miller, Maximillian, Zeng, Zishuo, Bromberg, Yana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012514/
https://ncbi.nlm.nih.gov/pubmed/33816556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.635382
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