Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial

AIMS/HYPOTHESIS: Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune...

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Vydáno v:Diabetologia
Hlavní autoři: Assfalg, Robin, Knoop, Jan, Hoffman, Kristi L., Pfirrmann, Markus, Zapardiel-Gonzalo, Jose Maria, Hofelich, Anna, Eugster, Anne, Weigelt, Marc, Matzke, Claudia, Reinhardt, Julia, Fuchs, Yannick, Bunk, Melanie, Weiss, Andreas, Hippich, Markus, Halfter, Kathrin, Hauck, Stefanie M., Hasford, Jörg, Petrosino, Joseph F., Achenbach, Peter, Bonifacio, Ezio, Ziegler, Anette-Gabriele
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012335/
https://ncbi.nlm.nih.gov/pubmed/33515070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05376-1
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