An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation

Cancer cell–intrinsic programmed cell death protein-1 (PD-1) has emerged as a tumor regulator in an immunity-independent manner, but its precise role in modulating tumor behaviors is complex, and how PD-1 is regulated in cancer cells is largely unknown. Here, we identified PD-1 as a direct target of...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Cao, Zhijie, Kon, Ning, Liu, Yajing, Xu, Wenbin, Wen, Jia, Yao, Han, Zhang, Mi, Wu, Zhen, Yan, Xiaojun, Zhu, Wei-Guo, Gu, Wei, Wang, Donglai
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011965/
https://ncbi.nlm.nih.gov/pubmed/33789902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf4148
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