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Thermodynamics and Kinetics of Ion Permeation in Wild-Type and Mutated Open Active Conformation of the Human α7 Nicotinic Receptor

[Image: see text] Molecular studies of human pentameric ligand-gated ion channels (LGICs) expressed in neurons and at neuromuscular junctions are of utmost importance in the development of therapeutic strategies for neurological disorders. We focus here on the nicotinic acetylcholine receptor nAChR-...

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Detalhes bibliográficos
Publicado no:J Chem Inf Model
Principais autores: Cottone, Grazia, Chiodo, Letizia, Maragliano, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011927/
https://ncbi.nlm.nih.gov/pubmed/32803965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.0c00549
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