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Conformational Changes in Acetylcholine Binding Protein Investigated by Temperature Accelerated Molecular Dynamics

Despite the large number of studies available on nicotinic acetylcholine receptors, a complete account of the mechanistic aspects of their gating transition in response to ligand binding still remains elusive. As a first step toward dissecting the transition mechanism by accelerated sampling techniq...

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Hlavní autoři: Mohammad Hosseini Naveh, Zeynab, Malliavin, Therese E., Maragliano, Luca, Cottone, Grazia, Ciccotti, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923797/
https://ncbi.nlm.nih.gov/pubmed/24551117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088555
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