Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis

Autophagy modulates lipid turnover, cell survival, inflammation, and atherogenesis. Scavenger receptor class B type I (SR-BI) plays a crucial role in lysosome function. Here, we demonstrate that SR-BI regulates autophagy in atherosclerosis. SR-BI deletion attenuated lipid-induced expression of autop...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Tao, Huan, Yancey, Patricia G., Blakemore, John L., Zhang, Youmin, Ding, Lei, Jerome, W. Gray, Brown, Jonathan D., Vickers, Kasey C., Linton, MacRae F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011903/
https://ncbi.nlm.nih.gov/pubmed/33661763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94229
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