Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts

Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/micr...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhang, Qian, Mesner, Larry D., Calabrese, Gina M., Dirckx, Naomi, Li, Zhu, Verardo, Angela, Yang, Qian, Tower, Robert J., Faugere, Marie-Claude, Farber, Charles R., Clemens, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011892/
https://ncbi.nlm.nih.gov/pubmed/33792563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142580
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