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Fitting a naturally scaled point system to the ACMG/AMP variant classification guidelines

Recently, we demonstrated that the qualitative American College of Medical Genetics and Genomics/ Association for Medical Pathology (ACMG/AMP) guidelines for evaluation of Mendelian disease gene variants are fundamentally compatible with a quantitative Bayesian formulation. Here, we show that the un...

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Publicat a:Hum Mutat
Autors principals: Tavtigian, Sean V., Harrison, Steven M., Boucher, Kenneth M., Biesecker, Leslie G.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011844/
https://ncbi.nlm.nih.gov/pubmed/32720330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.24088
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