Bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica nanoparticles: a promising nanocarrier for delivery of Cas9-sgRNA ribonucleoproteine

BACKGROUND: There is a great interest in the efficient intracellular delivery of Cas9-sgRNA ribonucleoprotein complex (RNP) and its possible applications for in vivo CRISPR-based gene editing. In this study, a nanoporous mediated gene-editing approach has been successfully performed using a bi-funct...

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Detalhes bibliográficos
Publicado no:J Nanobiotechnology
Main Authors: Salekdeh, Pardis Rahimi, Ma’mani, Leila, Tavakkoly-Bazzaz, Javad, Mousavi, Hossein, Modarressi, Mohammad Hossein, Salekdeh, Ghasem Hosseini
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011395/
https://ncbi.nlm.nih.gov/pubmed/33789675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-021-00838-z
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