Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo

BACKGROUND: Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As a natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the regulation mechanism and precise target of this substance remain undiscovered...

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Bibliografiset tiedot
Julkaisussa:J Exp Clin Cancer Res
Päätekijät: Huang, Hai, Park, Song, Zhang, Haibo, Park, Sijun, Kwon, Wookbong, Kim, Enugyung, Zhang, Xiujuan, Jang, Soyoung, Yoon, Duhak, Choi, Seong-Kyoon, Yi, Jun-koo, Kim, Sung-hyun, Dong, Zigang, Lee, Mee-hyun, Ryoo, Zaeyoung, Kim, Myoung Ok
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2021
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010944/
https://ncbi.nlm.nih.gov/pubmed/33785035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01895-w
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