Live Imaging of SARS-CoV-2 Infection in Mice Reveals Neutralizing Antibodies Require Fc Function for Optimal Efficacy

Neutralizing antibodies (NAbs) are effective in treating COVID-19 but the mechanism of immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment in prophylaxis and therapy of K18-hACE2 mice intranasally infected w...

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Vydáno v:bioRxiv
Hlavní autoři: Ullah, Irfan, Prévost, Jérémie, Ladinsky, Mark S, Stone, Helen, Lu, Maolin, Anand, Sai Priya, Beaudoin-Bussières, Guillaume, Symmes, Kelly, Benlarbi, Mehdi, Ding, Shilei, Gasser, Romain, Fink, Corby, Chen, Yaozong, Tauzin, Alexandra, Goyette, Guillaume, Bourassa, Catherine, Medjahed, Halima, Mack, Matthias, Chung, Kunho, Wilen, Craig B, Dekaban, Gregory A., Dikeakos, Jimmy D., Bruce, Emily A., Kaufmann, Daniel E, Stamatatos, Leonidas, McGuire, Andrew T., Richard, Jonathan, Pazgier, Marzena, Bjorkman, Pamela J., Mothes, Walther, Finzi, Andrés, Kumar, Priti, Uchil, Pradeep D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010726/
https://ncbi.nlm.nih.gov/pubmed/33791699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.22.436337
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