Monocytes From Patients With Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis Are Hyperresponsive to Interferon Gamma

OBJECTIVE: To investigate the activation of the IFNγ signaling pathway in monocytes of patients with secondary hemophagocytic lymphohistiocytosis (sHLH)/macrophage activation syndrome (MAS) and to evaluate whether levels of phosphorylated STAT1 represent a biomarker for the identification of patient...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Pascarella, Antonia, Bracaglia, Claudia, Caiello, Ivan, Arduini, Alessia, Moneta, Gian Marco, Rossi, Marianna Nicoletta, Matteo, Valentina, Pardeo, Manuela, De Benedetti, Fabrizio, Prencipe, Giusi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010171/
https://ncbi.nlm.nih.gov/pubmed/33815425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.663329
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