SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells

Viruses require specific cellular receptors to infect their target cells. Angiotensin-converting enzyme 2 (ACE2) is a cellular receptor for two divergent coronaviruses, SARS coronavirus (SARS-CoV) and human coronavirus NL63 (HCoV-NL63). In addition to hostcell receptors, lysosomal cysteine proteases...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Huang, I-Chueh, Bosch, Berend Jan, Li, Fang, Li, Wenhui, Lee, Kyoung Hoa, Ghiran, Sorina, Vasilieva, Natalya, Dermody, Terence S., Harrison, Stephen C., Dormitzer, Philip R., Farzan, Michael, Rottier, Peter J.M., Choe, Hyeryun
Formato: Artigo
Idioma:Inglês
Publicado em: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2006
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010168/
https://ncbi.nlm.nih.gov/pubmed/16339146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M508381200
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