Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2

Human angiotensin-converting enzyme 2 (ACE2) is a functional receptor for SARS coronavirus (SARS-CoV). Here we identify the SARS-CoV spike (S)-protein-binding site on ACE2. We also compare S proteins of SARS-CoV isolated during the 2002–2003 SARS outbreak and during the much less severe 2003–2004 ou...

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Hoofdauteurs: Li, Wenhui, Zhang, Chengsheng, Sui, Jianhua, Kuhn, Jens H, Moore, Michael J, Luo, Shiwen, Wong, Swee-Kee, Huang, I-Chueh, Xu, Keming, Vasilieva, Natalya, Murakami, Akikazu, He, Yaqing, Marasco, Wayne A, Guan, Yi, Choe, Hyeryun, Farzan, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2005
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142572/
https://ncbi.nlm.nih.gov/pubmed/15791205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600640
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