The Autocatalytic Release of a Putative RNA Virus Transcription Factor from Its Polyprotein Precursor Involves Two Paralogous Papain-like Proteases That Cleave the Same Peptide Bond

The largest replicative protein of coronaviruses is known as p195 in the avian infectious bronchitis virus (IBV) and p210 (p240) in the mouse hepatitis virus. It is autocatalytically released from the precursors pp1a and pp1ab byone zinc finger-containing papain-like protease (PLpro) in IBV and by t...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ziebuhr, John, Thiel, Volker, Gorbalenya, Alexander E.
Format: Artigo
Language:Inglês
Published: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2001
Subjects:
Genomics Proteomics and Bioinformatics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009867/
https://ncbi.nlm.nih.gov/pubmed/11431476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M104097200
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