Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

BACKGROUND: Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified....

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Sui, Qiaoqi, Liu, Dingxin, Jiang, Wu, Tang, Jinghua, Kong, Lingheng, Han, Kai, Liao, Leen, Li, Yuan, Ou, Qingjian, Xiao, Binyi, Liu, Guochen, Ling, Yihong, Chen, Jiewei, Liu, Zexian, Zuo, Zhixiang, Pan, Zhizhong, Zhou, Penghui, Zheng, Jian, Ding, Pei-Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Immunotherapy Biomarkers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009229/
https://ncbi.nlm.nih.gov/pubmed/33782107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001498
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