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Practical Synthesis of C-1 Deuterated Aldehydes Enabled by NHC Catalysis
The recent surge in applications of deuterated pharmaceutical agents has created an urgent demand for synthetic methods that efficiently generate deuterated building blocks. Here we show that N-heterocyclic carbenes (NHC) promote a reversible hydrogen-deuterium exchange (HDE) reaction with simple al...
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| Vydáno v: | Nat Catal |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8008838/ https://ncbi.nlm.nih.gov/pubmed/33791590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41929-019-0370-z |
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