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Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding
Rac1 is a small member of the Rho GTPase family. One of the most important downstream effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational activation of PAK1 by Rac1 has oncogenic signaling effects. Here, although we focus on Rac1-PAK1 interaction by atomic-force...
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| Publicado no: | Biophys J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8008323/ https://ncbi.nlm.nih.gov/pubmed/33515600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.01.016 |
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