Antibody Afucosylation Augments CD16-Mediated Serial Killing and IFNγ Secretion by Human Natural Killer Cells

One mechanism by which monoclonal antibodies (mAb) help treat cancer or autoimmune disease is through triggering antibody-dependent cellular cytotoxicity (ADCC) via CD16 on Natural Killer (NK) cells. Afucosylation is known to increase the affinity of mAbs for CD16 on NK cells and here, we set out to...

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Publicado en:Front Immunol
Autores principales: Karampatzakis, Alexandros, Brož, Petr, Rey, Camille, Önfelt, Björn, Cruz De Matos, Gabriela Dos Santos, Rycroft, Daniel, Ambrose, Ashley, Davis, Daniel M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008054/
https://ncbi.nlm.nih.gov/pubmed/33796107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.641521
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