Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells

Natural Killer (NK) cells can engage multiple virally infected or tumor cells sequentially and deliver perforin for cytolytic killing of these targets. Using microscopy to visualize degranulation from individual NK cells, we found that repeated activation via the Fc receptor CD16 decreased the amoun...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Srpan, Katja, Ambrose, Ashley, Karampatzakis, Alexandros, Saeed, Mezida, Cartwright, Adam N.R., Guldevall, Karolin, De Matos, Gabriela Dos Santos Cruz, Önfelt, Björn, Davis, Daniel M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122987/
https://ncbi.nlm.nih.gov/pubmed/29967280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201712085
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