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Late-stage oxidative C(sp(3))–H methylation
Frequently referred to as the “magic methyl effect”, installation of methyl groups, especially α to heteroatoms, has been shown to drastically increase the potency of bioactive molecules(1–3). Current methylation methods display limited scope and have not been demonstrated in complex settings(1). He...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8006464/ https://ncbi.nlm.nih.gov/pubmed/32179876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2137-8 |
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