Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets

More than two decades have elapsed since the publication of the first genome sequence of Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine gene essentiality in the pathogen. Despite this, target-based approaches have not yielded drugs that have progressed to cl...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Oh, Sangmi, Trifonov, Lena, Yadav, Veena D., Barry, Clifton E., Boshoff, Helena I.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cellular and Infection Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005628/
https://ncbi.nlm.nih.gov/pubmed/33791235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2021.611304
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