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Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells

Cell-to-cell heterogeneity in metabolism plays an unknown role in physiology and pharmacology. To functionally characterize cellular variability in metabolism, we treated cells with inhibitors of oxidative phosphorylation (OXPHOS) and monitored their responses with live-cell reporters for ATP, ADP/A...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Kosaisawe, Nont, Sparta, Breanne, Pargett, Michael, Teragawa, Carolyn K., Albeck, John G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005262/
https://ncbi.nlm.nih.gov/pubmed/33561427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2021.01.014
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