Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry

Background: Monoclonal antibodies (mAbs) against cancer biomarkers are key reagents in diagnosis and therapy. One such relevant biomarker is a preferentially expressed antigen in melanoma (PRAME) that is selectively expressed in many tumors. Knowing mAb’s epitope is of utmost importance for understa...

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Pubblicato in:Int J Mol Sci
Autori principali: Sivaccumar, Jwala Priyadarsini, Leonardi, Antonio, Iaccarino, Emanuela, Corvino, Giusy, Sanguigno, Luca, Chambery, Angela, Russo, Rosita, Valletta, Mariangela, Latino, Debora, Capasso, Domenica, Doti, Nunzianna, Ruvo, Menotti, Sandomenico, Annamaria
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8003813/
https://ncbi.nlm.nih.gov/pubmed/33804612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22063166
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