Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422

The hepatitis C virus (HCV) E2 envelope glycoprotein is crucial for virus entry into hepatocytes. A conserved region of E2 encompassing amino acids 412 to 423 (epitope I) and containing Trp420, a residue critical for virus entry, is recognized by several broadly neutralizing antibodies. Peptides emb...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sandomenico, Annamaria, Leonardi, Antonio, Berisio, Rita, Sanguigno, Luca, Focà, Giuseppina, Focà, Annalia, Ruggiero, Alessia, Doti, Nunzianna, Muscariello, Livio, Barone, Daniela, Farina, Claudio, Owsianka, Ania, Vitagliano, Luigi, Patel, Arvind H., Ruvo, Menotti
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794675/
https://ncbi.nlm.nih.gov/pubmed/26819303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02397-15
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